Temperature Dependence of Two Key Interstellar Reactions of H3+: O(3P) + H3+ and CO + H3+

Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y

Nucleosomal incorporation of specialized histone variants is an important mechanism to generate different functional chromatin states. Here, we describe the identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y. Their messenger RNAs are found in certain human cell lines, in addition to several normal and malignant human tissues. In keeping with the...

Nuclear Spin Dependence in Reactions of H3 in the Laboratory and the Interstellar Medium By

Hydrogen is the most abundant element in the universe. For this reason, the chemistry of the interstellar medium is largely dominated by the interaction of hydrogenic neutrals and ions. The hydrogen molecule, H2, and the simplest polyatomic ion, H3 , each exist in one of two forms identified as ortho or para, which are defined by their total nuclear spins. These spin modifications have differen...

Enigma of H3 + in Diffuse Interstellar Clouds

1. INTRODUCTION H 3 + is of fundamental importance to interstellar chemistry both because it is a hydrogenic species (and >90% of all nuclei in the universe are hydrogen nuclei; see Figure 1) and because it serves as the universal protonator, initiating a chain of ion-neutral reactions that is responsible for the formation of most interstellar molecules. The chemistry of H 3 + in dense (molecul...

H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis

Dynamic changes in histone modifications under various physiological cues play important roles in gene transcription and cancer. Identification of new histone marks critical for cancer development is of particular importance. Here we show that, in a glucose-dependent manner, E3 ubiquitin ligase NEDD4 ubiquitinates histone H3 on lysine 23/36/37 residues, which specifically recruits histone acety...

Reactions Involving the Nuclear Spin Modifications of H3 and H2; Implications for the Interstellar Medium