Temperature-Insensitive Label-Free Sensors for Human IgG Based on S-Tapered Optical Fiber Sensors

We demonstrate a temperature-insensitive and high-sensitive label-free biosensor for low-concentration Human IgG detection based on S-tapered optical fiber (STF). The sensor is sensitive to local refractive index changes has high robustness against temperature noise without control system. sensitivity of the −0.02nm/°C in range 25°C-45°C. Within 15 minutes at room temperature, average drift center wavelength 0.04 nm. calibration experiments that STFs liquid achieved sensing precision nm 538.62 nm/RIU. are applied concentration measurement multiple diluted ex vivo biomolecule solutions. results showed were reliable its lower limit was demonstrated as 28 ng/ml. With advantages temperature-insensitive, compact size, low cost, precision, real-time detection, fast response, good specificity, this STF sensors promising antigen applications.