TERATOGENIC ACTION OF ADENINE ON MOUSE EMBRYOS

Teratogenic action of adenine on mouse embryos.

Several purine analogues are reported to show a teratogenic action in mammalian embryos when ad ministered at calculated dosage [reviewed by Giroud and Tuchmann-Duplessis-(1), Cahen (2) and Nishimura (3, 4); Kury et al. (5)]. We established that some methylated xanthines such as theophylline, theobromine and caffeine induce skeletal defects and subcutaneous hematoma in mice (6). Hypoxanthine al...

TERATOGENIC EFFECTS OF LITHIUM CARBONATE ON DEVELOPMENT OF MOUSE EMBRYOS

teratogenic effects of lithium carbonate on development of mouse embryos

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Teratogenic effects of silymarin on mouse fetuses

Objective: Silybum marianum has been used for centuries in herbal medicine for treatment of liver diseases. Currently, there is no data available on the possible effects of silymarin on fetal development. This study aimed to investigate the teratogenic effect of silymarin on BALB/c mice fetuses. Materials and Methods: A total of 40 pregnant mice were divided into 4 groups of 10 mice each. Three...

Teratogenic activity of methadone hydrochloride in mouse and chick embryos.

Teratogenic activity of methadone HC1 (Physeptone, Burroughs Wellcome and Co.) was tested on inbred JBT/Jd and outbred Q strain mouse embryos and on chick embryos. 22-24 mg/kg injected subcutaneously on the 9th day of pregnancy caused by the 13th day exencephaly in 56 out of 479 JBT/Jd embryos but after 32 mg/kg only in 1 out of 220 of the Q strain. Some affected JBT/Jd embryos showed also rach...