Tethered primary hepatocyte spheroids on polystyrene multi-well plates for high-throughput drug safety testing
نویسندگان
چکیده
منابع مشابه
Tethered spheroids as an in vitro hepatocyte model for drug safety screening.
Hepatocyte spheroids mimic many in vivo liver-tissue phenotypes but increase in size during extended culture which limits their application in drug testing applications. We have developed an improved hepatocyte 3D spheroid model, namely tethered spheroids, on RGD and galactose-conjugated membranes using an optimized hybrid ratio of the two bioactive ligands. Cells in the spheroid configuration ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-61699-4