Thalamic Local Field Potentials Are Related to Long-Term DBS Effects in Tourette Syndrome
نویسندگان
چکیده
منابع مشابه
Clinical review of DBS for Tourette Syndrome.
Deep brain stimulation for Tourette Syndrome is an emerging therapy for patients with severe, disabling tics. The complexity of symptoms associated with TS present challenges for electrode target selection and evaluation of outcome that distinguish it from other disorders for which DBS has been studied. Accumulating data have been sufficiently promising to justify further study. Yet, many quest...
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L. Ackermansa, I. Neunerb, Y. Temela,c, A. Duitsd,e, J. Kuhnf and V. Visser-Vandewalleg,∗ Department of Neurosurgery, Maastricht University Medical Centre, Maastricht, The Netherlands Department of Psychiatry and Psychotherapy, RWTH Aachen University, Aachen, Germany European Graduate School of Neuroscience (EURON), Faculty of Health, Medicine and Life Science, Maastricht, The Netherlands Depar...
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BACKGROUND Tourette syndrome (TS) is thought to result from dysfunction of the associative-limbic territories of the basal ganglia, and patients with severe symptoms of TS respond poorly to medication. High-frequency stimulation has recently been applied to patients with TS in open studies using the centromedian-parafascicular complex (CM-Pf) of the thalamus, the internal globus pallidus (GPi),...
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Optimal electrophysiological placement of the DBS electrode may lead to better long term clinical outcomes. Inter-subject anatomical variability and limitations in stereotaxic neuroimaging increase the complexity of physiological mapping performed in the operating room. Microelectrode single unit neuronal recording remains the most common intraoperative mapping technique, but requires significa...
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We used [F-18]fallypride PET in six adults with Tourette syndrome and age-matched controls to assess extrastriatal dopamine 2 (D2) receptors. D2 receptor availability was significantly lower in the orbitofrontal cortex, primary motor cortex, anterior cingulate gyrus, mediodorsal nucleus of thalamus, and hippocampus, areas important for motivation and reward, sensory gating, movement, and attent...
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ژورنال
عنوان ژورنال: Frontiers in Neurology
سال: 2021
ISSN: 1664-2295
DOI: 10.3389/fneur.2021.578324