The 1842 “Plug Plot” in Stockport

Ether anaesthesia, 1842-1900.

Dmd052415 1835..1842

Drug-induced liver injury is the most frequent reason for market withdrawal of approved drugs, and is difficult to predict in animal models. Here, we analyzed transcriptomic data derived from shortand long-term cultured primary human hepatocytes (PHH) exposed to the well known human hepatotoxin chlorpromazine (CPZ). Samples were collected from five PHH cultures after short-term (1 and 3 days) a...

Dmd059352 1834..1842

Acyl glucuronides are reactive electrophilic metabolites implicated in the toxicity of carboxylic acid drugs. Valproyl 1-O-b-acyl glucuronide (VPA-G), which is a major metabolite of valproic acid (VPA), has been linked to the development of oxidative stress in VPA-treated rats. However, relatively little is known about the toxicity of in situ generated VPA-G and its contribution to VPA hepatoto...

Op-brai150097 1833..1842

Memory loss after brain injury can be a source of considerable morbidity, but there are presently few therapeutic options for restoring memory function. We have previously demonstrated that burst stimulation of the fornix is able to significantly improve memory in a rodent model of traumatic brain injury. The present study is a preliminary investigation with a small group of cases to explore wh...

Baron Larrey (1766-1842)

in 1766, three years before Napoleon Bonoparte, whose loving follower Larrey was destined to become. His birthplace was in the romantic region of the High Pyreniees, at the village of Beaudeau. At the period of Larrey's birth, centuries of misrule were about to culminate in a mighty catastrophe for Franice. At the beginning of the eighteenth century, France was the most powerful nation in Europ...