The actin cortex at a glance
نویسندگان
چکیده
منابع مشابه
Actin and cellular architecture at a glance.
Shape is an important property of all cells, from unicellular bacteria to the individual cells of complex metazoans. Even for unicellular organisms, the establishment, maintenance and changing of cell morphology is a dynamic process in time and space, and is the result of both intrinsic genetic programmes, such as those that govern division, and of extrinsic factors, such as chemotaxis or osmot...
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Actin and myosin II form the archetypical molecular motor complex. Myosin II, like all members of the myosin superfamily, is an actin-activated ATPase that uses the energy released when ATP is hydrolyzed to do work. Although we typically associate work with muscle contraction, cell motility and cell division, many nuclear processes require energy. Historically, the notion that the nucleus conta...
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Actin functions in a multitude of cellular processes owing to its ability to polymerize into filaments, which can be further organized into higher-order structures by an array of actin-binding and regulatory proteins. Therefore, research on actin and actin-related functions relies on the visualization of actin structures without interfering with the cycles of actin polymerization and depolymeri...
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Cells respond to external stimuli by rapidly remodeling their actin cytoskeleton. At the heart of this function lies the intricately controlled regulation of individual filaments. The barbed end of an actin filament is the hotspot for the majority of the biochemical reactions that control filament assembly. Assays performed in bulk solution and with single filaments have enabled characterizatio...
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Cells use their cytoskeletons to move, polarise, divide and maintain organisation within multicellular tissues. Actin is a highly conserved essential building block of the cytoskeleton that forms cables and struts, which are constantly remodelled by more than 100 different actin-binding proteins. The initiation of new actin filaments and their subsequent organisation is a key step in the develo...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2018
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.186254