The Association of NAD(P)H Oxidase p22phox With Diabetic Nephropathy Is Still Uncertain: Response to Doi, Noiri, and Tokunaga
نویسندگان
چکیده
منابع مشابه
Role of NADPH Oxidase in Hypertension and Diabetic Nephropathy
Oxidative stress plays an important role in the development of renal damage in diabetes and hypertension. The major source of oxidative stress is nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived superoxide anion (O2 ) that directly damage cell and also activate signaling of cell proliferation, adhesion molecules, and fibrosis. O2 .also inactivates endothelium derived nitric o...
متن کاملExpression of NADH/NADPH oxidase p22phox in human coronary arteries.
BACKGROUND NADH/NADPH oxidase is an important source of superoxide in the vasculature. Recently, we found that polymorphism of the gene p22phox, a critical component of this oxidase, is associated with a risk of coronary artery disease. The aim of this study was to investigate the localization of p22phox in human coronary arteries and to examine its difference in expression between nonatheroscl...
متن کاملAssociation between NADPH Oxidase p22phox C242T Polymorphism and Ischemic Cerebrovascular Disease: A Meta-Analysis
BACKGROUND Epidemiological studies have evaluated the association between nicotinamide adenine dinucleotide phosphate (NADPH) oxidase p22(phox) C242T polymorphism and risk of ischemic cerebrovascular disease (ICVD), but the results remain inconclusive. This meta-analysis was therefore designed to clarify these controversies. METHODOLOGY/PRINCIPAL FINDINGS Systematic searches of electronic dat...
متن کاملAssociation of the p22phox component of NAD(P)H oxidase with susceptibility to diabetic nephropathy in patients with type 1 diabetes.
OBJECTIVE Increased production of reactive oxygen species (ROS) in diabetes is thought to play a major role in the pathogenesis of diabetic microvascular complications such as nephropathy and retinopathy. The NAD(P)H oxidase complex is an important source of ROS in the vasculature. The p22 subunit is polymorphic with a C242T variant that changes histidine-72 for a tyrosine in the potential heme...
متن کاملNADPH oxidase p22phox gene expression in ulcerative colitis.
BACKGROUND/AIMS Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which catalyzes the formation of reactive oxygen species (ROS) in phagocytic cells, has five subunits: p67phox ("phox"refers to "phagocyte oxidase"), p47phox, p40phox, p22phox, and gp91phox (catalytic subunit). Oxidative stress resulting from the accumulation of ROS and/or defective removal of ROS by antioxidants has d...
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ژورنال
عنوان ژورنال: Diabetes Care
سال: 2004
ISSN: 0149-5992,1935-5548
DOI: 10.2337/diacare.27.6.1519