The binding of TIA-1 to RNA C-rich sequences is driven by its C-terminal RRM domain
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چکیده
منابع مشابه
RNA binding of T-cell intracellular antigen-1 (TIA-1) C-terminal RNA recognition motif is modified by pH conditions.
T-cell intracellular antigen-1 (TIA-1) is a DNA/RNA-binding protein that regulates critical events in cell physiology by the regulation of pre-mRNA splicing and mRNA translation. TIA-1 is composed of three RNA recognition motifs (RRMs) and a glutamine-rich domain and binds to uridine-rich RNA sequences through its C-terminal RRM2 and RRM3 domains. Here, we show that RNA binding mediated by eith...
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ژورنال
عنوان ژورنال: RNA Biology
سال: 2014
ISSN: 1547-6286,1555-8584
DOI: 10.4161/rna.28801