The calcium-sensing receptor as a mediator of inflammation
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چکیده
منابع مشابه
Calcium Sensing Receptor as a Novel Mediator of Adipose Tissue Dysfunction: Mechanisms and Potential Clinical Implications
Obesity is currently a serious worldwide public health problem, reaching pandemic levels. For decades, dietary and behavioral approaches have failed to prevent this disease from expanding, and health authorities are challenged by the elevated prevalence of co-morbid conditions. Understanding how obesity-associated diseases develop from a basic science approach is recognized as an urgent task to...
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Critical to cell fate in many cell types is the ability to sense and respond to acute changes in free ionized extracellular calcium concentration ([Ca(2+)](o)). Such tight control is mediated by the activation of a protein known as the extracellular-calcium-sensing receptor (CaR). CaR belongs to the 'family C' of G-protein-coupled receptors and was the first G-protein-coupled receptor to be ide...
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activities and by electron microscopy. The higher-density fractions (1.2-1.5~-sucrose) contained actomyosin fibrils, mitochondria and sacroplasmic reticulum, and were enriched in cytochrome oxidase and Caz+-dependent adenosine triphosphatase. The endoplasmic-reticulum marker, NADPH-cytochtome c reductase, was found throughout the gradient. Lower-density fractions (0.75-1 .OM sucrose) were enric...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2016
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2015.08.006