The carbon tetrachloride model in mice
نویسندگان
چکیده
منابع مشابه
Metformin protects against carbon tetrachloride hepatotoxicity in mice.
In the present study, the hepatoprotective effect of metformin (Met), a dimethylbiguanide anti-hyperglycemic, was examined in a mouse model of liver damage induced by chronic repeated administration of carbon tetrachloride (CCl(4)) (5 microl/kg, twice a week for 12 weeks). Met, when given orally in drinking water at an estimated daily dose of 25 or 50 mg/kg for 10 weeks starting 2 weeks after C...
متن کاملCarbon tetrachloride-induced liver damage in asialoglycoprotein receptor-deficient mice.
The asialoglycoprotein (ASGP) receptor is an abundant hepatocyte-specific receptor involved in receptor-mediated endocytosis. This receptor's abundance and function is decreased by chronic ethanol administration prior to the appearance of pathology such as necrosis or inflammation. Hence, this study aimed to determine if ASGP receptor function is required to protect against liver injury by util...
متن کاملCarbon Tetrachloride in Helminthiasis
In the Journal of the American Mcdical Association of November 19th, 1921, there appeared a note by Maurice C. Hall on the use of Carbon tetrachloride for the removal of hookworms in animals. Dr. Hall is the senior zoologist, United States Bureau of Animal Industry, and he found this drug to be a powerful anthelmintic in dogs* and suggested its trial in human uncinariasis. Carbon tetrachloride ...
متن کاملHepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice
Objective(s): The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl4)-induced liver toxicity. Materials and Methods: Hepatotoxicity was induced in mice by a single subcutaneous injection (SC) of CCl4. The LCB was administered orally once a day for seven days (PO) as pretreatment at three doses of 1, 5, and...
متن کاملNos2 deficiency enhances carbon tetrachloride-induced liver injury in aged mice
Objective(s): As a multifunctional molecule, NO has different effects on liver injury. The present work aimed to investigate the effects of Nos2 knockout (KO) on acute liver injury in aged mice treated with carbon tetrachloride (CCl4). Materials and Methods: The acute liver injury model was produced by CCl4 at 10 ml/kg body weight in 24-...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Laboratory Animals
سال: 2015
ISSN: 0023-6772,1758-1117
DOI: 10.1177/0023677215571192