The changes of mitochondrial cytochrome c and GABAergic neuron in neuropathic pain model
نویسندگان
چکیده
منابع مشابه
The changes of mitochondrial cytochrome c and GABAergic neuron in neuropathic pain model
BACKGROUND Role of cytochrome c (Cyt c) is an apoptogenic agent under certain conditions. The mitochondrial permeability transition pore (MPTP) plays an important role in cell death since it opens, leading to mitochondrial swelling and release of Cyt c, which initiates apoptosis. By inhibiting the opening of MPTP, cyclosporine A (CSA) may contribute to maintaining mitochondrial homeostasis. We ...
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چکیده ندارد.
15 صفحه اولForebrain GABAergic Neuron Precursors Integrate into Adult Spinal Cord and Reduce Injury-Induced Neuropathic Pain
Neuropathic pain is a chronic debilitating disease characterized by mechanical allodynia and spontaneous pain. Because symptoms are often unresponsive to conventional methods of pain treatment, new therapeutic approaches are essential. Here, we describe a strategy that not only ameliorates symptoms of neuropathic pain but is also potentially disease modifying. We show that transplantation of im...
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Despite extensive investigations, the main mechanisms underlying neuropathic pain development are still not fully understood and there is no effective treatment for that. So intensive research is being done for finding new, efficient analgesic drugs. 56 male Wistar rats (230±30) were divided into 7 groups (n=8); control, sham, CCI and 3 Umbelliprenin groups (25, 50 and 100 microgram/rat)...
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Background: Neuritis is one of the causes of neuropathic pains. It is proved that turmeric and curcumin have anti-neuritis effect that may be reduce of neuropathic pain. Objective: In this study, effects of turmeric and curcumin have been evaluated on behavioral response resulted from chronic constriction injury (CCI) in rat. Methods: In this experimental study Wistar male rat (200-250 gr) were...
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ژورنال
عنوان ژورنال: Korean Journal of Anesthesiology
سال: 2012
ISSN: 2005-6419,2005-7563
DOI: 10.4097/kjae.2012.62.4.365