The Codon Usage of Lowly Expressed Genes Is Subject to Natural Selection
نویسندگان
چکیده
منابع مشابه
Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes
Codon usage data has been compiled for 110 yeast genes. Cluster analysis on relative synonymous codon usage revealed two distinct groups of genes. One group corresponds to highly expressed genes, and has much more extreme synonymous codon preference. The pattern of codon usage observed is consistent with that expected if a need to match abundant tRNAs, and intermediacy of tRNA-mRNA interaction ...
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متن کاملThe effect of context on synonymous codon usage in genes with low codon usage bias.
The effect of neighbouring bases on the usage of synonymous codons in genes with low codon usage bias in yeast and E. coli is examined. The codon adaptation index is employed to identify a group of genes in each organism with low codon usage bias, which are likely to be weakly expressed. A similar pattern is found in complementary sequences with respect to synonymous usage of A vs G or of U vs ...
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ژورنال
عنوان ژورنال: Genome Biology and Evolution
سال: 2018
ISSN: 1759-6653
DOI: 10.1093/gbe/evy084