The Comparative Effect of Combination of Metformin and Megestrol Acetate With Megestrol Acetate Alone on Endometrial Growth Disorders
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چکیده
منابع مشابه
Conservative therapy with metformin plus megestrol acetate for endometrial atypical hyperplasia
OBJECTIVE To compare the efficacy of metformin plus megestrol acetate (MA) with that of MA alone for treating endometrial atypical hyperplasia (EAH). METHODS This pilot study included 16 EAH patients who met at least one metabolic syndrome (MS) criterion and received either adjunctive metformin plus MA (MET group) or MA monotherapy (MA group). Each patient in the MA group received 160 mg of M...
متن کاملMegestrol acetate in cachexia and anorexia
The aim is to review major clinical trials that have used megestrol acetate (MA) in the treatment of cachexia across several disease states. A review of general usage and potential side-effects are discussed. A theory that the newly approved nanocrystal formation of MA can better deliver this potent medication for treatment will also be reviewed.
متن کاملThe effect of megestrol acetate on growth of HepG2 cells in vitro and in vivo.
PURPOSE Hepatocellular carcinoma (HCC) is generally considered as a sex hormone-dependent tumor, and hormonal therapy has been proposed as a strategy for the treatment of HCC. The aim of the study is to investigate the effect of megestrol acetate, a synthetic progesteronal agent, on growth of HepG2 cells in vitro and in vivo. EXPERIMENTAL DESIGN Cell growth in vitro was assessed by a colormet...
متن کاملNew Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate.
As many substances are poorly soluble in water and thus possess decreased bioavailability, creating orally administered forms of these substances is a challenge. The objective of this study was to determine whether the solubility of megestrol acetate, a Biopharmaceutical Classification System (BCS) class II drug, can be improved by using a newly-synthesized surfactant (Rofam 70: a rapeseed meth...
متن کاملMegestrol acetate for the treatment of anorexia-cachexia syndrome.
BACKGROUND Megestrol acetate (MA) is currently used to improve appetite and to increase weight in cancer-associated anorexia. In 1993 MA was approved by the USA's Federal Drug Administration for the treatment of anorexia, cachexia, or unexplained weight loss in patients with AIDS. The mechanism by which MA increases appetite is unknown, and its effectiveness for anorexia and cachexia in neoplas...
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ژورنال
عنوان ژورنال: International Journal of Women's Health and Reproduction Sciences
سال: 2017
ISSN: 2330-4456
DOI: 10.15296/ijwhr.2018.35