The complement receptor 3 (CD11b/CD18) agonist Leukadherin-1 suppresses human innate inflammatory signalling
نویسندگان
چکیده
منابع مشابه
The complement receptor 3 (CD11b/CD18) agonist Leukadherin‐1 suppresses human innate inflammatory signalling
Complement receptor 3 (CR3, CD11b/CD18) is a multi-functional receptor expressed predominantly on myeloid and natural killer (NK) cells. The R77H variant of CD11b, encoded by the ITGAM rs1143679 polymorphism, is associated robustly with development of the autoimmune disease systemic lupus erythematosus (SLE) and impairs CR3 function, including its regulatory role on monocyte immune signalling. ...
متن کاملComplement Receptor Type 1 Suppresses Human B Cell Functions in SLE Patients
Complement receptors (CRs) play an integral role in innate immunity and also function to initiate and shape the adaptive immune response. Our earlier results showed that complement receptor type 1 (CR1, CD35) is a potent inhibitor of the B cell receptor- (BCR-) induced functions of human B lymphocytes. Here we show that this inhibition occurs already at the initial steps of B cell activation si...
متن کاملPorphyromonas gingivalis interactions with complement receptor 3 (CR3): innate immunity or immune evasion?
Porphyromonas gingivalis is a major oral pathogen associated with periodontal disease. In this paper, we review the mechanism whereby this organism induces a proadhesive signaling pathway for activation of complement receptor 3 (CR3; CD11b/CD18) and discuss its biological significance on the basis of published findings by our lab and other investigators. The proadhesive pathway is initiated whe...
متن کاملFolding and conformational studies on SCR1-3 domains of human complement receptor 1.
Short consensus repeats SCR3 and SCR1-3 are soluble recombinant proteins, consisting of the third and first three N-terminal domains of complement receptor 1, respectively, which retain some anti-complement activity. The conformational stabilities and folding/unfolding of SCR3 and SCR1-3 have been studied using circular dichroism and equilibrium and pre-equilibrium fluorescence spectroscopy. De...
متن کاملMouse podocyte complement factor H: the functional analog to human complement receptor 1.
Complement factor H (Cfh) is a key plasma protein in humans and animals that serves to limit alternative pathway complement activation in plasma, as well as in local sites such as capillaries of the glomerulus and eye. It was shown that rodent Cfh on platelets is the functional analogue to human erythrocyte complement receptor 1 with a role that is distinct from plasma Cfh and that Cfh is also ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2016
ISSN: 0009-9104
DOI: 10.1111/cei.12803