The Complexity Hypothesis Revisited: Connectivity Rather Than Function Constitutes a Barrier to Horizontal Gene Transfer
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منابع مشابه
The complexity hypothesis revisited: connectivity rather than function constitutes a barrier to horizontal gene transfer.
Horizontal gene transfer (HGT) is a prevalent and a highly important phenomenon in microbial species evolution. One of the important challenges in HGT research is to better understand the factors that determine the tendency of genes to be successfully transferred and retained in evolution (i.e., transferability). It was previously observed that transferability of genes depends on the cellular p...
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Increasingly, studies of genes and genomes are indicating that considerable horizontal transfer has occurred between prokaryotes. Extensive horizontal transfer has occurred for operational genes (those involved in housekeeping), whereas informational genes (those involved in transcription, translation, and related processes) are seldomly horizontally transferred. Through phylogenetic analysis o...
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Overemphasis on hypothesis testing--and the use of P values to dichotomise significant or non-significant results--has detracted from more useful approaches to interpreting study results, such as estimation and confidence intervals. In medical studies investigators are usually interested in determining the size of difference of a measured outcome between groups, rather than a simple indication ...
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Horizontal gene transfer (HGT) is the movement of genetic information between organisms, a process that includes the spread of antibiotic resistance genes among bacteria (except for those from parent to offspring), fueling pathogen evolution. Many resistance genes evolved long ago in natural environments with no anthropogenic influence but these genes are now rapidly spreading to and among huma...
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Horizontal or Lateral Gene Transfer (HGT or LGT) is the transmission of portions of genomic DNA between organisms through a process decoupled from vertical inheritance. In the presence of HGT events, different fragments of the genome are the result of different evolutionary histories. This can therefore complicate the investigations of evolutionary relatedness of lineages and species. Also, as ...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2010
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msq333