The Corticotropin-Releasing Factor Family: Physiology of the Stress Response
نویسندگان
چکیده
منابع مشابه
The physiology of corticotropin-releasing factor (CRF).
Corticotropin-releasing factor (CRF) was characterized, purified and synthesized in 1981 by Vale. The composition of this 41 amino-acid peptide varies slightly from one species to another. Its principal origin is the paraventricular nucleus of the hypothalamus and, by the portal vessels, it reaches the adenohypophysis where it stimulates the corticotrophs. The effects of CRF have been analysed ...
متن کاملCorticotropin-releasing hormone physiology
Corticotropin-releasing hormone (CRH), also known as corticotropin-releasing factor, is a highly conserved peptide hormone comprising 41 amino acid residues. Its name derives from its role in the anterior pituitary, where it mediates the release of corticotropin (ACTH) leading to the release of adrenocortical steroids. CRH is the major hypothalamic activator of the hypothalamic–pituitary– adren...
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15 صفحه اولCentral corticotropin releasing factor and social stress
Social interactions are a main source of stress in vertebrates. Social stressors, as well as other stressors, activate the hypothalamic-pituitary-adrenal (HPA) axis resulting in glucocorticoid release. One of the main components of the HPA axis is corticotropin releasing factor (CRF). The neuropeptide CRF is part of a peptide family including CRF, urocortin 1-3, urotensin 1-3, and sauvagine. Th...
متن کاملInteraction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response.
The hypothalamic neuropeptides hypocretins (orexins) play a crucial role in the stability of arousal and alertness. We tested whether the hypocretinergic system is a critical component of the stress response activated by the corticotropin-releasing factor (CRF). Our results show that CRF-immunoreactive terminals make direct contact with hypocretin-expressing neurons in the lateral hypothalamus ...
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ژورنال
عنوان ژورنال: Physiological Reviews
سال: 2018
ISSN: 0031-9333,1522-1210
DOI: 10.1152/physrev.00042.2017