The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target
نویسندگان
چکیده
منابع مشابه
The crystal structure of TAL effector PthXo1 bound to its DNA target.
DNA recognition by TAL effectors is mediated by tandem repeats, each 33 to 35 residues in length, that specify nucleotides via unique repeat-variable diresidues (RVDs). The crystal structure of PthXo1 bound to its DNA target was determined by high-throughput computational structure prediction and validated by heavy-atom derivatization. Each repeat forms a left-handed, two-helix bundle that pres...
متن کاملEditorial: NAR Awards 2012
Amanda Nga-Sze Mak (Fred Hutchinson Cancer Research Center, Seattle, WA, USA) The Crystal Structure of TAL Effector Pthxo1 Bound to its DNA Target Amanda Nga-Sze Mak, Philip Bradley, Raul A. Cernadas, Adam J. Bogdanove, Barry L. Stoddard The crystal structure of PthXo1 bound to its DNA target was determined with the use of a novel high-throughput computational structure prediction method, that ...
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ژورنال
عنوان ژورنال: Science
سال: 2012
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1216211