The effect of butorphanol postconditioning on myocardial ischaemia reperfusion injury in rats

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The effect of butorphanol postconditioning on myocardial ischaemia reperfusion injury in rats.

OBJECTIVES Butorphanol tartrate is a synthetic opioid partial agonist analgesic. Butorphanol targets the heart, mainly via κ-opioid receptor (κ-OR) activation. The purpose of this study was to determine the effect and mechanism underlying butorphanol postconditioning (B-Post) on myocardial ischaemia reperfusion injury in rats. METHODS Seventy-five male Sprague-Dawley rats were randomly divide...

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Myocardial postconditioning: reperfusion injury revisited

CORONARY HEART DISEASE is the leading cause of death in the Western world and represents one of the major burdens on healthcare systems today. Targeting those strategies that limit the damage sustained as a result of a lethal ischemic insult has been a major goal for many years. One of these strategies, termed ischemic preconditioning, in which brief nonlethal episodes of ischemia protect the m...

متن کامل

Myocardial postconditioning: reperfusion injury revisited

CORONARY HEART DISEASE is the leading cause of death in the Western world and represents one of the major burdens on healthcare systems today. Targeting those strategies that limit the damage sustained as a result of a lethal ischemic insult has been a major goal for many years. One of these strategies, termed ischemic preconditioning, in which brief nonlethal episodes of ischemia protect the m...

متن کامل

Myocardial postconditioning: reperfusion injury revisited

CORONARY HEART DISEASE is the leading cause of death in the Western world and represents one of the major burdens on healthcare systems today. Targeting those strategies that limit the damage sustained as a result of a lethal ischemic insult has been a major goal for many years. One of these strategies, termed ischemic preconditioning, in which brief nonlethal episodes of ischemia protect the m...

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ژورنال

عنوان ژورنال: Interactive CardioVascular and Thoracic Surgery

سال: 2013

ISSN: 1569-9293,1569-9285

DOI: 10.1093/icvts/ivt516