The Effectiveness of Ecklonia Cava Kjellman Extract in Improving Menopausal Syndrome in Osteoporosis and Depression

Ecklonia cava (EC) is a natural material commonly used to decrease swelling, allergy, cancer, and sleep issues. Using EC has been reported regulate hormones during ovarian failure in an aromatase inhibition rodent model. The aim of this study was investigate EC’s benefits on ovariectomized female mice. Hormone replacement therapy beneficial menopause, but the risk side effects increases. In present study, alkaline phosphatase (ALP) activity tryptophan hydroxylases (TPHs) expression were studied after extracts incorporated as elemental, phloroglucinol, eckol, dieckol, 6,6′-biekcol, 8,8′-bieckol. vivo following seven groups 10-week-old Balb/c mice evaluated over 8 weeks: normal (Sham), (OVX), restraint stressed (OVX + R), 17β-estradiol-treated R E2), fluoxetine-treated EC-extract-treated EC150 or OVX EC300). serum lipid profile, bone loss, depressive symptoms investigated restraint-stressed vitro models, ALP dose-dependently upregulated by EC, including 8,8′-bieckol, RBL-2H3 cells. transcripts TPH1 TPH2 induced and/or its elements (phloroglucinol, 8,8′-bieckol) re-uptake serotonin (5-HT) also decreased ingredients such cholesterol triglyceride levels downregulated treatment. mineral density (BMD) determined EC-treated groups, metabolism markers, CTX osteocalcin, reduced levels. depression experiments revealed that immobility time shortened forced-swimming test Moreover, level promoted treatment These results showed extract inhibits loss menopausal mouse model modulating markers (CTX osteocalcin)