The Efficacy of Interferon Beta in Delaying Conversion to Clinically Definite Multiple Sclerosis
نویسندگان
چکیده
منابع مشابه
Interferon beta-1a decreased the risk for conversion to clinically definite multiple sclerosis.
P a t i e n t s 308 patients (mean age 28 y, 64% women) who had presented with a first neurologic episode (unifocal or multifocal involvement of the central nervous system) suggesting MS in the previous 3 months, with ≥ 1 abnormality evident during the neurologic examination and a positive magnetic resonance imaging (MRI) scan result. Exclusion criteria included immunosuppressive or immunomodul...
متن کاملPredictors and Conversion Rate of Clinically Isolated Syndrome to Clinically Definite Multiple Sclerosis: A Follow-up Study in Patients Living in the Southern Part of Iran
Background: Clinical course of Clinically Isolated Syndrome (CIS) is variable, and identifying patients who will eventually develop Multiple Sclerosis (MS) is essential. Objectives: To assess the conversion rate of CIS to Clinically Definite Multiple Sclerosis (CDMS) and its predictors in southern Iran. Materials & Methods: A total of 143 CIS patients registered to Fars Multiple Sclerosis Soc...
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We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevale...
متن کاملComparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
We compared MRI criteria used to predict conversion of suspected multiple sclerosis to clinically definite multiple sclerosis. Seventy-four patients with clinically isolated neurological symptoms suggestive of multiple sclerosis were studied with MRI. Logistic regression analysis was used to remove redundant information, and a diagnostic model was built after each MRI parameter was dichotomized...
متن کاملTreatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes.
OBJECTIVE To assess efficacy, safety, and tolerability of every-other-day interferon beta-1b treatment in patients with a first clinical event suggestive of multiple sclerosis (MS) (clinically isolated syndrome). METHODS We conducted a multicenter, randomized, double-blind, placebo-controlled trial. Patients with a first clinical demyelinating event and at least two clinically silent brain MR...
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ژورنال
عنوان ژورنال: International Journal of MS Care
سال: 2010
ISSN: 1537-2073
DOI: 10.7224/1537-2073-12.1.42