The essential YycFG two-component system controls cell wall metabolism inBacillus subtilis
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منابع مشابه
YycH regulates the activity of the essential YycFG two-component system in Bacillus subtilis.
Of the numerous two-component signal transduction systems found in bacteria, only a very few have proven to be essential for cell viability. Among these is the YycF (response regulator)-YycG (histidine kinase) system, which is highly conserved in and specific to the low-G+C content gram-positive bacteria. Given the pathogenic nature of several members of this class of bacteria, the YycF-YycG sy...
متن کاملYycH and YycI interact to regulate the essential YycFG two-component system in Bacillus subtilis.
The YycFG two-component system is the only signal transduction system in Bacillus subtilis known to be essential for cell viability. This system is highly conserved in low-G+C gram-positive bacteria, regulating important processes such as cell wall homeostasis, cell membrane integrity, and cell division. Four other genes, yycHIJK, are organized within the same operon with yycF and yycG in B. su...
متن کاملIdentification of Genes Controlled by the Essential YycFG Two-Component System Reveals a Role for Biofilm Modulation in Staphylococcus epidermidis
Biofilms play a crucial role in the pathogenicity of Staphylococcus epidermidis, while little is known about whether the essential YycFG two-component signal transduction system (TCS) is involved in biofilm formation. We used antisense RNA (asRNA) to silence the yycFG TCS in order to study its regulatory functions in S. epidermidis. Strain 1457 expressing asRNA yycF exhibited a significant dela...
متن کاملEssentiality, bypass, and targeting of the YycFG (VicRK) two-component regulatory system in gram-positive bacteria.
Bacterial two-component systems and phosphorelays are woven into the fabric of cellular regulatory mechanisms ensuring homeostatic equilibrium under a wide variety of environmental conditions (reviewed in references 13, 15, 18, 19, 23, and 28). Of the individual two-component regulatory systems (TCSs), YycFG has excited interest for several reasons and has been the topic of many recent studies....
متن کاملThe Eukaryotic-Like Ser/Thr Kinase PrkC Regulates the Essential WalRK Two-Component System in Bacillus subtilis
Most bacteria contain both eukaryotic-like Ser/Thr kinases (eSTKs) and eukaryotic-like Ser/Thr phosphatases (eSTPs). Their role in bacterial physiology is not currently well understood in large part because the conditions where the eSTKs are active are generally not known. However, all sequenced Gram-positive bacteria have a highly conserved eSTK with extracellular PASTA repeats that bind cell ...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2007
ISSN: 0950-382X,1365-2958
DOI: 10.1111/j.1365-2958.2007.05782.x