The evoked compound nerve action potential is shaped by the electrical pulse-width

Abstract Introduction : Despite its central role in medicine electrical stimulation (ES) is still limited by selectivity. Different reports did assess effects of different waveforms, intensities, and frequency on the activation threshold nerve fibres with diameters. We aimed to extend this knowledge investigating effect short monophasic rectangular pulses (1, 2, 5, 10, 50, 100 200 μs) recruitment order. Methods: The sciatic rats was stimulated, evoked compound action potential (CNAP) measured at two sites tibialis nerve, using epineural electrodes. Changes delay, amplitude, shape CNAP were analyzed. Results: amplitude delay significantly affected pulse-width (PW). duration increased longer PW, while decreased. Discussion: Found changes are likely caused time point excitation individual neuron fibres, depending field strength exposure time. This might be particular interest when selecting PWs for design validation patterns analysis experimental clinical observations.