The exercise tolerance dependence on epicardial fat thickness, right ventricular hypertrophy and right ventricular global function in patients with metabolic syndrome

Abstract Background The importance of the evaluation right compartments heart is beyond doubts. Right ventricle (RV) plays one leading roles in assessing prognosis patients, especially context metabolic syndrome (MS), insulin resistance and visceral obesity. Several trials highlight epicardial fat thickness (EFT) as a novel marker obesity proximity to RV does not exclude its direct effect on ventricular function. More that, EFT represents metabolically active organ with wide range bioeffects that could potentiate cardiometabolic risk profile patients MS Purpose objective present study was evaluate impact obesity, hypertrophy diastolic global function exercise capacity (i.e., duration (ED), equivalents (METs)) persevered left Methods We included 97 subjects (mean age 54±8.7 years) controls without 53±9.6 years, P=0.13). defined by ≥3 criteria International Diabetes Federation American Heart Association/National Heart, Lung, Blood Institute. Using 2D echocardiography we assessed function: ratio early late tricuspid flow velocities (Et/At), velocity annular (Et/e't), Et deceleration time (DT); Tei index pulsed tissue Doppler; free wall thickness; (EFT). All participants underwent ECG stress test (cycle ergometry) determined ED METs. Results Et/At, Et/e't, EtDT were significantly deteriorated group (all P<0.05). Also, showed significant correlations parameters MS, respectively: Et/At (r=−0.432, P<0.05; r=−0.523, P<0.01), Et/e't (r=0.334, P<0.01; r=0.291, (r=0.411, r=0.593, P<0.001). positively correlated (r=0.628, P<0.001) (r=0.623, In bivariate analysis found METs negatively associated (r=−0.208, P=0.033), (r=−0.295, (r=−0.515, P<0.001), (r=−0.504, (r=−0.646, P<0.05) group. important negative correlation same Systolic did show statistically or ED. Multivariate regression thickness, independently (P<0.05). Conclusions Our findings support tolerance syndrome. Funding Acknowledgement Type funding sources: None.