The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling

Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease

Fibroblasts comprise the largest cell population in the myocardium. In heart disease, the number of fibroblasts is increased either by replication of the resident myocardial fibroblasts, migration and transformation of circulating bone marrow cells, or by transformation of endothelial/epithelial cells into fibroblasts and myofibroblasts. The primary function of fibroblasts is to produce structu...

Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling.

BACKGROUND Inflammation has been implicated in the pathogenesis of heart failure (HF), but knowledge about the production and role of inflammatory actors remains incomplete. On the basis of its role in vascular inflammation, vascular proliferation, and matrix degradation, we hypothesized a role for the chemokine CXCL16 in the pathogenesis of myocardial remodeling and development of HF. METHOD...

Extracellular matrix remodeling in hypertensive heart disease.

everal decades ago, the severity of heart failure was gauged ccording to a depression in myocardial contractility, dened as that biochemical property of cardiac muscle that etermines the extent of shortening independent of its nitial length and the load against which it shortens. athematical models were used to derive indices of conractility (1). These theoretical constructs included a conracti...

Bioactive Extracellular Matrix Scaffold Promotes Adaptive Cardiac Remodeling and Repair

Matrix remodeling in experimental and human heart failure: a possible regulatory role for TIMP-3.

In the failing heart, an imbalance in matrix metalloproteinases (MMPs) and their biological regulators, the tissue inhibitors of MMPs (TIMPs), may result in cardiac dilatation from matrix degradation. We hypothesized that a reduction of myocardial TIMP-3 is associated with adverse matrix remodeling in both human and experimental heart failure. Cardiomyopathic hamsters at age 15 wk (normal), 25 ...