The fibrosis-cell death axis in heart failure

The role of cell death in heart failure.

In this issue of Circulation Research, Guerra and colleagues1 report that myocyte death in the failing human heart is gender dependent. This work is in continuation of Dr Anversa’s numerous reports on the occurrence of apoptosis, necrosis, and proliferation in the failing human heart, as well as under various experimental conditions including, among others, aging and myocardial infarction in ra...

Cardiac fibrosis in heart failure

The prevalence of Heart Failure (HF) is approximately 1-2% in adult population, rising to more than 10% of elderlies over 70 years of age 1 2. Epidemiological studies show high incidence and prevalence of HF among elderlies. The prognosis of HF in this population is poor with rising cases of hospitalization, comorbidity and health costs 3-5. Cardiac remodeling is a cardinal process mediating th...

Onset of heart failure determines the hepatic cell death pattern.

BACKGROUND AND RATIONALE Acute and chronic heart failure (HF) may affect the liver, but the underlying mechanisms that lead to progressive liver damage are poorly understood. The hepatic cytokeratin-18 (CK18) epitopes M65 and M30 have been reported to distinguish between overall (necrotic) and apoptotic cell death, respectively. We aimed to evaluate the predominant hepatic cell death pattern in...

Death begets failure in the heart.

Recently, low--but abnormal--rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.

of the American Heart Association Heart Failure 1 Death in Heart Failure : a Community Perspective Danielle