The free energy of locking a ring: Changing a deoxyribonucleoside to a locked nucleic acid
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چکیده
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The free energy of locking a ring: Changing a deoxyribonucleoside to a locked nucleic acid
Locked nucleic acid (LNA), a modified nucleoside which contains a bridging group across the ribose ring, improves the stability of DNA/RNA duplexes significantly, and therefore is of interest in biotechnology and gene therapy applications. In this study, we investigate the free energy change between LNA and DNA nucleosides. The transformation requires the breaking of the bridging group across t...
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ژورنال
عنوان ژورنال: Journal of Computational Chemistry
سال: 2017
ISSN: 0192-8651
DOI: 10.1002/jcc.24692