The HAMP Signal Relay Domain Adopts Multiple Conformational States through Collective Piston and Tilt Motions
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منابع مشابه
The HAMP Signal Relay Domain Adopts Multiple Conformational States through Collective Piston and Tilt Motions
The HAMP domain is a linker region in prokaryotic sensor proteins and relays input signals to the transmitter domain and vice versa. Functional as a dimer, the structure of HAMP shows a parallel coiled-coil motif comprising four helices. To date, it is unclear how HAMP can relay signals from one domain to another, although several models exist. In this work, we use molecular simulation to test ...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2013
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1002913