The importance of cytogenetic and molecular aberrations in multiple myeloma

Multiple myeloma (MM) is a heterogeneous clonal malignancy of plasma cells characterized by cytogenetic and molecular abnormalities. Chromosomal abnormalities are present at diagnosis can evolve during the progression MM. Metaphase karyotyping fluorescence in situ hybridization considered standard diagnostic procedures performed clinical practice. These test results required to determine Revised International Staging System classification, treatment algorithms, short- long-term prognoses. Given dynamic development research, we should expect further progress better understanding biology MM changes patient care coming years.