The influence of solution choice on fluid resuscitation in patients with septic shock

The aim. Compare the hemodynamic effects and safety of infusion balanced crystalloid solution, sorbitol-based standard solution (0.9 % sodium chloride).
 Materials methods. A prospective randomized clinical trial was carried out, study included 68 adult patients, who had active surgical infection, were in a state septic shock. corresponding with volume 500 ml used for resuscitation. Hemodynamic other laboratory parameters monitored.
 Results. There no significant difference mean arterial pressure (MAP) between 3 groups before 45th minute (p>0.05), from 50th to 2 hours they found only NS Sorb (p <0.05). No statistically heart rate (HR) obtained any measurement (p> 0.05). Cardiac output (CO) oxygen delivery (DO2) did not differ until 35 min 0.05) up 40 0.05); after 45 min, also After sorbitol-containing polyionic acid-base blood significantly improved. applied dose safe renal function clotting shock this study. But may be associated decrease number platelets. Daily changes by APACHE II scores each group significant. 7-day 28-day mortality (p>0.05).
 Conclusions. In our study, 1.9 lactate 6 sorbitol most effective treatment shock, it can as supplement solutions. When using (Ringer's acetate) 0.07 L-malonic acid, platelet count should monitored more often