The Innate Immune System and Inflammatory Priming: Potential Mechanistic Factors in Mood Disorders and Gulf War Illness

The Gulf War and illness by association.

The symptoms of Gulf War Syndrome (GWS) closely correspond to the physiological and behavioural sequelae of an interleukin-1 (IL-1) mediated sickness response. We propose that this response can account for the variability in its symptomatology. Furthermore, the persistence of GWS can be accounted for by an associative process, whereby the smells/tastes of war become linked with the physiologica...

Gulf War Illness and the Health of Gulf War Veterans Scientific Findings and Recommendations Research Advisory Committee on Gulf War Veterans’ Illnesses Gulf War Illness and the Health of Gulf War Veterans Scientific Findings and Recommendations

Update on Gulf War illness.

Background: Cryptic species are two or more distinct but morphologically similar species that were classified as a single species. During the past two decades we observed an exponential growth of publications on cryptic species. Recently published reviews have demonstrated cryptic species have profound consequences on many biological disciplines. It has been proposed that their distribution is ...

MOOD DISORDERS AND MEDICAL ILLNESS Mood Disorders and Allostatic Load

The brain controls both the physiologic and the behavioral coping responses to daily events as well as major stressors, and the nervous system is itself a target of the mediators of those responses through circulating hormones. The amygdala and hippocampus interpret what is stressful and regulate appropriate responses. The amygdala becomes hyperactive in posttraumatic stress disorder (PTSD) and...

Complementary proteomic approaches reveal mitochondrial dysfunction, immune and inflammatory dysregulation in a mouse model of Gulf War Illness

PURPOSE Long-term consequences of combined pyridostigmine bromide (PB) and permethrin (PER) exposure in C57BL6/J mice using a well-characterized mouse model of exposure to these Gulf War (GW) agents were explored at the protein level. EXPERIMENTAL DESIGN We used orthogonal proteomic approaches to identify pathways that are chronically impacted in the mouse CNS due to semiacute GW agent exposu...