The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction
نویسندگان
چکیده
منابع مشابه
Up-Regulation of Intestinal Phosphate Transporter NaPi-IIb (SLC34A2) by the Kinases SPAK and OSR1.
BACKGROUND/AIMS SPAK (SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase 1), kinases controlled by WNK (with-no-K[Lys] kinase), are powerful regulators of cellular ion transport and blood pressure. Observations in gene-targeted mice disclosed an impact of SPAK/OSR1 on phosphate metabolism. The present study thus tested whether SPAK and/or OSR1 contributes to ...
متن کاملHigh Phosphorus Diet-Induced Changes in NaPi-IIb Phosphate Transporter Expression in the Rat Kidney: DNA Microarray Analysis
The mechanism by which phosphorus levels are maintained in the body was investigated by analyzing changes in gene expression in the rat kidney following administration of a high phosphorus (HP) diet. Male Wistar rats were divided into two groups and fed a diet containing 0.3% (control) or 1.2% (HP) phosphorous for 24 days. Phosphorous retention was not significantly increased in HP rats, but fr...
متن کاملRegulation of intestinal phosphate transport. II. Metabolic acidosis stimulates Na(+)-dependent phosphate absorption and expression of the Na(+)-P(i) cotransporter NaPi-IIb in small intestine.
During metabolic acidosis, P(i) serves as an important buffer to remove protons from the body. P(i) is released from bone together with carbonate buffering protons in blood. In addition, in the kidney, the fractional excretion of phosphate is increased allowing for the excretion of more acid equivalents in urine. The role of intestinal P(i) absorption in providing P(i) to buffer protons and com...
متن کاملAge-Dependent Regulation of Rat Intestinal Sodium-Phosphate Cotransporter (NaPi-IIb) by 1,25-(OH)2 Vitamin D3
The current studies were designed to characterize type IIb sodium-phosphate cotransporter (NaPi-IIb) expression and to assess the effect of 1,25-(OH)2 vitamin D3 (vit-D3) on NaPi-IIb gene expression during rat ontogeny. Sodium-dependent Pi absorption by intestinal brush-border membrane vesicles (BBMV) decreases with age, and NaPi-IIb gene expression also decreases proportionally with age. Vit-D...
متن کاملRegulation of small intestinal Na-Pi type IIb cotransporter by dietary phosphate intake.
Dietary restriction of phosphate is a well-known stimulator (acting indirectly via vitamin D3) of small intestinal apical Na-Picotransport. In the present study, we document by Western blots and immunohistochemistry that, in mice, a low-Pi diet given for several days leads (in parallel to a stimulation of Na-Pi cotransport) to an increase of the abundance of the type IIb Na-Pi cotransporter in ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-10390-2