The LEGATOS technique: A new tissue?validated dynamic contrast?enhanced MRI method for whole?brain, high?spatial resolution parametric mapping
نویسندگان
چکیده
Purpose A DCE-MRI technique that can provide both high spatiotemporal resolution and whole-brain coverage for quantitative microvascular analysis is highly desirable but currently challenging to achieve. In this study, we sought develop validate a novel dual-temporal (DTR) DCE-MRI-based methodology deriving accurate, high-spatial parameters. Methods Dual injection DTR was performed composite high-temporal tissue gadolinium-based-contrast agent (GBCA) concentration curves were constructed. The low-spatial first-pass GBCA then reconstructed pixel-by-pixel higher spatial using process call LEGATOS. accuracy of kinetic parameters (Ktrans, vp, ve) derived LEGATOS evaluated through simulations in vivo studies 17 patients with vestibular schwannoma (VS) 13 glioblastoma (GBM). Tissue from 15 tumors examined markers microvessels (CD31) cell density (hematoxylin eosin [H&E]). Results parameter maps offered superior improved compared the use data alone, provided discrimination plasma volume vascular leakage effects other approaches, correlated vascularity (P ? 0.003) 0.006). Conclusion method be used generate estimates DCE-MRI.
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2021
ISSN: ['0740-3194', '1522-2594']
DOI: https://doi.org/10.1002/mrm.28842