The Manuscript Option Dissertation: Multiple Perspectives

In Silico Perspectives on the Prediction of the PLP’s Epitopes involved in Multiple Sclerosis

Background: Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system (CNS). The main cause of the MS is yet to be revealed, but the most probable theory is based on the molecular mimicry that concludes some infections in the activation of T cells against brain auto-antigens that initiate the disease cascade.Objectives: The Purpose of this research is the...

Reject option with multiple thresholds

can be obtained using the so-called “reject” option. Namely, the patterns that are the most likely to be misclassified are rejected (i.e., they are not classified); they are then handled by more sophisticated procedures (e.g., a manual classification is performed). However, handling high reject rates is usually too time-consuming for application purposes. Therefore, a trade-off between error an...

Perspectives in Biology and Medicine – Accepted, Uncorrected Manuscript Perspectives in Biology and Medicine

Exploring Multiple Usability Perspectives

Industrial usability work often fails to produce the expected impact on software products even though significant resources have been used on uncovering problems and suggesting improvements. So, it seems that feedback from industrial usability work lacks persuasiveness, i.e. it fails to convince the key stakeholders that actions need to be taken. This study reports from interviews with 26 stake...

Perspectives on multiple sclerosis.

There is no question that MR imaging is presently the best method for imaging multiple sclerosis (MS); yet, even today, MS remains a clinical diagnosis, with the relationship between clinical course and MR findings still problematic (1, 2). MR imaging appears to be the most important test performed in the diagnostic workup of MS; it has much greater impact than CSF analysis and evoked potential...