The mechanism of non‑coding RNAs in medulloblastoma (Review)

Medulloblastoma (MB) is one of the most common malignant tumors central nervous system in children. Although surgery, radiotherapy and chemotherapy have resulted considerable progress treatment this disease, prognosis patients with MB remains very poor. Therefore, highly specific molecular targeted treatment, which can improve therapeutic efficacy reduce side effects MB, has become a research hotspot. In recent years, non‑coding RNAs (ncRNAs), were initially considered to be transcriptional noise, been shown possess regulatory functions. A series ncRNAs identified, including microRNAs circular RNAs, affect expression genes variety tumors. These lead formation complex proteins or they directly participate protein synthesis order regulate occurrence development The aim present review article was summarize studies that explored ability MB.