The Molecular Perspective: Cyclooxygenase-2
نویسندگان
چکیده
منابع مشابه
The molecular perspective: cyclooxygenase-2.
course, cancer prevention starts at home. We can stay away from smoke, solvents, and sunlight, avoiding unnecessary risks to our cells. We can also eat healthy foods like fruits and vegetables that are filled with protective antioxidants and cleansing fiber. But researchers are now looking to chemistry to provide new compounds to reduce the risk of cancer. The goal is to create a long-term prev...
متن کاملCyclooxygenase-2 (COX-2): a molecular target in prostate cancer.
Epidemiological studies provided the first evidence that COX may be involved in the pathogenesis of cancer. In the process of carcinogenesis and in the route of intracellular signalling during carcinogenesis, COX-2 expression may be a universal phenomenon. In general, COX-2 is up-regulated throughout the tumorigenic process, from early hyperplasia to metastatic disease. COX-2 has been reported ...
متن کاملCyclooxygenase-1 and -2: Molecular Targets for Cervical Neoplasia
Cyclooxygenase (COX) is a key enzyme responsible for inflammation, converting arachidonic acid to prostaglandin and thromboxane. COX has at least two isoforms, COX-1 and COX-2. While COX-1 is constitutively expressed in most tissues for maintaining physiologic homeostasis, COX-2 is induced by inflammatory stimuli including cytokines and growth factors. Many studies have shown that COX-2 contrib...
متن کاملReview: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis.
Cancer-induced angiogenesis is the result of increased expression of angiogenic factors, or decreased expression of anti-angiogenic factors, or a combination of both events. For instance, in colon cancer, the malignant cells, the stromal fibroblasts, and the endothelial cells all exhibit strong staining for cyclooxygenase-2 (COX-2), the rate-controlling enzyme in prostaglandin (PG) synthesis. I...
متن کاملCyclooxygenase-2 in the kidney.
Prostaglandins are produced constitutively by many tissues in the body, including brain, gut, and kidney, and their synthesis increases at sites of inflammation. Cyclooxygenase (COX), the enzyme responsible for the initial rate-limiting metabolism of arachidonic acid to prostaglandin G2 and subsequently to prostaglandin H2, was first purified in ram seminal vesicles and was cloned in 1988 by De...
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ژورنال
عنوان ژورنال: Stem Cells
سال: 2000
ISSN: 1066-5099,1549-4918
DOI: 10.1634/stemcells.18-3-227