The netrin protein family
نویسندگان
چکیده
منابع مشابه
A Novel Member of the Netrin Family, β-Netrin, Shares Homology with the β Chain of Laminin
The netrins are a family of laminin-related molecules. Here, we characterize a new member of the family, beta-netrin. beta-Netrin is homologous to the NH(2) terminus of laminin chain short arms; it contains a laminin-like domain VI and 3.5 laminin EGF repeats and a netrin C domain. Unlike other netrins, this new netrin is more related to the laminin beta chains, thus, its name beta-netrin. An i...
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The multifunctional protein netrin-1 was initially discovered as the main attractive cue for commissural axon guidance by acting through its receptor DCC. Recently, we have shown that netrin-1 also interacts with the orphan transmembrane receptor amyloid precursor protein (APP). APP is cleaved by proteases, generating amyloid-β peptide, the main component of the amyloid plaques that are associa...
متن کاملA Novel Member of the Netrin Family, b -Netrin, Shares Homology with the b Chain of Laminin: Identification, Expression, and Functional Characterization
The netrins are a family of laminin-related molecules. Here, we characterize a new member of the family, b -netrin. b -Netrin is homologous to the NH 2 terminus of laminin chain short arms; it contains a laminin-like domain VI and 3.5 laminin EGF repeats and a netrin C domain. Unlike other netrins, this new netrin is more related to the laminin b chains, thus, its name b -netrin. An initial ana...
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Although the pivotal implication of the host-encoded Prion protein, PrP, in the neuropathology of transmissible spongiform encephalopathy is known for decades, its biological role remains mostly elusive. Genetic inactivation is one way to assess such issue but, so far, PrP-knockout mice did not help much. However, recent reports involving (1) further studies of these mice during embryogenesis, ...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2009
ISSN: 1465-6906
DOI: 10.1186/gb-2009-10-9-239