The Non-Mevalonate Pathway to Isoprenoid Biosynthesis: A Potential Source of New Drug Targets
نویسندگان
چکیده
منابع مشابه
The non-mevalonate pathway of isoprenoid precursor biosynthesis.
The recently discovered non-mevalonate biosynthetic route to isoprenoid precursors is an essential metabolic pathway in plants, apicomplexan parasites, and many species of bacteria. The pathway relies on eight enzymes exploiting different cofactors and metal ions. Structural and mechanistic data now exist for most components of the pathway though there remain some gaps in our knowledge. The ind...
متن کاملFive Questions about Non-Mevalonate Isoprenoid Biosynthesis
Isoprenoids (also referred to as terpenoids) are the largest group of natural products, comprising over 25,000 known compounds [1]. Each member of this class is assembled from 5-carbon (C5) isoprene units and derived metabolically from the basic building block isopentenyl pyrophosphate (IPP) and its isomer, dimethylallyl pyrophosphate (DMAPP). Subsequent metabolic reactions (such as cyclization...
متن کاملProperties and inhibition of the first two enzymes of the non-mevalonate pathway of isoprenoid biosynthesis.
Enzymes of the 1-deoxy-D-xylulose 5-phosphate/2-C-methylerythritol 4-phosphate (DOXP/MEP) pathway are targets for new herbicides and antibacterial drugs. Until now, no inhibitors for the DOXP synthase have been known of. We show that one of the breakdown products of the herbicide clomazone affects the DOXP synthase. One inhibitor of the non-mevalonate pathway, fosmidomycin, blocks the DOXP redu...
متن کاملStructure and reactivity in the non-mevalonate pathway of isoprenoid biosynthesis.
The function, structure and mechanism of two Escherichia coli enzymes involved in the non-mevalonate route of isoprenoid biosynthesis, 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase and 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, are reviewed. Comparisons of each with enzymes from microbial pathogens highlight important conservation of sequence suggestive of similarities in s...
متن کاملNon-mevalonate isoprenoid biosynthesis: enzymes, genes and inhibitors.
The essential steps of the novel non-mevalonate pathway of isopentenyl diphosphate and isoprenoid biosynthesis in plants are described. The first five enzymes and genes of this 1-deoxy-D-xylulose 5-phosphate/2-C-methyl-D-erythritol 4-phosphate (DOXP/MEP) pathway are known. The herbicide fosmidomycin specifically blocks the second enzyme, the DOXP reductoisomerase. The DOXP/MEP pathway is also p...
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ژورنال
عنوان ژورنال: CHIMIA International Journal for Chemistry
سال: 2008
ISSN: 0009-4293
DOI: 10.2533/chimia.2008.226