The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport

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The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport.

Transport of large cargo through the cytoplasm requires motor proteins and polarized filaments. Viruses that replicate in the nucleus of post-mitotic cells use microtubules and the dynein-dynactin motor to traffic to the nuclear membrane and deliver their genome through nuclear pore complexes (NPCs) into the nucleus. How virus particles (virions) or cellular cargo are transferred from microtubu...

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Nuclear entry and CRM1-dependent nuclear export of the Rous sarcoma virus Gag polyprotein.

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Nuclear export factor CRM1 interacts with nonstructural proteins NS2 from parvovirus minute virus of mice.

The nonstructural NS2 proteins of autonomous parvoviruses are known to act in a host cell-dependent manner and to play a role in viral DNA replication, efficient translation of viral mRNA, and/or encapsidation. Their exact function during the parvovirus life cycle remains, however, still obscure. We report here the characterization of the interaction with the NS2 proteins from the parvovirus mi...

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ژورنال

عنوان ژورنال: Journal of Cell Science

سال: 2017

ISSN: 1477-9137,0021-9533

DOI: 10.1242/jcs.203794