The post-inner cell mass intermediate: implications for stem cell biology and assisted reproductive technology

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The post-inner cell mass intermediate: implications for stem cell biology and assisted reproductive technology.

BACKGROUND Until recently, the temporal events that precede the generation of pluripotent embryonic stem cells (ESCs) and their equivalence with specific developmental stages in vivo was poorly understood. Our group has discovered the existence of a transient epiblast-like structure, coined the post-inner cell mass (ICM) intermediate or PICMI, that emerges before human ESC (hESCs) are establish...

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ژورنال

عنوان ژورنال: Human Reproduction Update

سال: 2015

ISSN: 1355-4786,1460-2369

DOI: 10.1093/humupd/dmv028