The presence of Tregs does not preclude immunity to reinfection with Leishmania braziliensis
نویسندگان
چکیده
منابع مشابه
Concomitant Immunity Induced by Persistent Leishmania major Does Not Preclude Secondary Re-Infection: Implications for Genetic Exchange, Diversity and Vaccination
BACKGROUND Many microbes have evolved the ability to co-exist for long periods of time within other species in the absence of overt pathology. Evolutionary biologists have proposed benefits to the microbe from 'asymptomatic persistent infections', most commonly invoking increased likelihood of transmission by longer-lived hosts. Typically asymptomatic persistent infections arise from strong con...
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We obtain analytical results about epidemics generated by the partial immunity model of Gomes et al. [3], in which infection confers partial immunity to reinfection. When the demographic process is excluded, the behavior switches from epidemic to endemic as the basic reproduction number R0 crosses the reinfection threshold R0=1σ. We derive formulas for two quantities characterizing the size of ...
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Leishmaniases are a group of diseases caused by protozoa of the genus Leishmania that affect millions of people worldwide. These diseases are caused by distinct Leishmania species, of which L. braziliensis, a New World representative of the Leishmania genus, has been the least studied. Although leishmaniasis caused by L. braziliensis induces a range of clinical manifestations ranging from mild ...
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Despite inducing very low IFN-γ response and highly attenuated in vivo, infection of mice with phosphoglycan (PG) deficient Leishmania major (lpg2-) induces protection against virulent L. major challenge. Here, we show that mice infected with lpg2- L. major generate Leishmania-specific memory T cells. However, in vitro and in vivo proliferation, IL-10 and IFN-γ production by lpg2- induced memor...
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ژورنال
عنوان ژورنال: International Journal for Parasitology
سال: 2012
ISSN: 0020-7519
DOI: 10.1016/j.ijpara.2012.05.006