The Proto-oncogene PKCι Regulates the Alternative Splicing of Bcl-x Pre-mRNA
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چکیده
منابع مشابه
The Proto-oncogene PKCι regulates the alternative splicing of Bcl-x pre-mRNA.
Two splice variants derived from the Bcl-x gene via alternative 5' splice site selection (5'SS) are proapoptotic Bcl-x(s) and antiapoptotic Bcl-x(L). Previously, our laboratory showed that apoptotic signaling pathways regulated the alternative 5'SS selection via protein phosphatase-1 and de novo ceramide. In this study, we examined the elusive prosurvival signaling pathways that regulate the 5'...
متن کاملSignaling and Regulation TheProto-oncogene PKCiRegulates the Alternative Splicing of Bcl-x Pre-mRNA
Two splice variants derived from the Bcl-x gene via alternative 50 splice site selection (50SS) are proapoptotic Bcl-x(s) and antiapoptotic Bcl-x(L). Previously, our laboratory showed that apoptotic signaling pathways regulated the alternative 50SS selection via protein phosphatase-1 and de novo ceramide. In this study, we examined the elusive prosurvival signaling pathways that regulate the 50...
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Epithelial-to-mesenchymal transition (EMT) and its reversal (MET) are crucial cell plasticity programs that act during development and tumor metastasis. We have previously shown that the splicing factor and proto-oncogene SF2/ASF impacts EMT/MET through production of a constitutively active splice variant of the Ron proto-oncogene. Using an in vitro model, we now show that SF2/ASF is also regul...
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The bcl-x gene appears to play a critical role in regulating apoptosis in the developing and mature CNS and following CNS injury. Two isoforms of Bcl-x are produced as a result of alternative pre-mRNA splicing: Bcl-xL (the long form) is anti-apoptotic, while Bcl-xS (short form) is pro-apoptotic. Despite the antagonistic activities of these two isoforms, little is known about how regulation of a...
متن کاملBcl-x pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia.
The bcl-x gene appears to play a critical role in regulating apoptosis in the developing and mature CNS and following CNS injury. Two isoforms of Bcl-x are produced as a result of alternative pre-mRNA splicing: Bcl-x(L) (the long form) is anti-apoptotic, while Bcl-x(S) (short form) is pro-apoptotic. Despite the antagonistic activities of these two isoforms, little is known about how regulation ...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2012
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-11-0363