The Reaction of Cyclopentanone with Cyanomethylene Reagents: Novel Synthesis of Pyrazole, Thiophene, and Pyridazine Derivatives

Reaction of Phenylhydrazo Ethylacetoacetate with Cyano Acetyl Hydrazine: Novel Synthesis of Pyridazine and Pyrazole Derivatives and Their Anti-tumor Evaluations

The reaction of phenylhydrazoethyl acetoacetate (1) with cyanoacetyl hydrazine (2) in an oil bath in the presence of ammonium acetate gave the pyridazine derivative 4. However, carrying the same reaction but in ethanolic/Et3N gave the pyrazole derivative 5. Compounds 4 and 5 were used in a series of heterocyclization reactions to afford products that showed anti-tumor activities towards three c...

wuthering heights and the concept of marality/a sociological study of the novel

to discuss my point, i have collected quite a number of articles, anthologies, and books about "wuthering heights" applying various ideas and theories to this fantastic story. hence, i have come to believe that gadamer and jauss are rightful when they claim that "the individaul human mind is the center and origin of all meaning," 3 that reading literature is a reader-oriented activity, that it ...

the evaluation of language related engagment and task related engagment with the purpose of investigating the effect of metatalk and task typology

abstract while task-based instruction is considered as the most effective way to learn a language in the related literature, it is oversimplified on various grounds. different variables may affect how students are engaged with not only the language but also with the task itself. the present study was conducted to investigate language and task related engagement on the basis of the task typolog...

Design and synthesis of pyrazole and thiophene derivatives with kinase inhibitory activity

Reaction of dicarbomethoxycarbene with thiophene derivatives.

Photolysis of derivatives of dimethylmalonate thiophene-S,C-ylide provides dicarbomethoxycarbene, which can react with thiophene to form dimethyl (2-thienyl)malonate. By generation of dicarbomethoxycarbene from the dibenzothiophene-based ylide in neat thiophene, it is shown that the thienylmalonate is not a product of rearrangement of the thiophene ylide, in contrast to thermolysis results. For...