The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling
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چکیده
منابع مشابه
Differential regulation of the REGγ–proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells
Proteasome activity is frequently enhanced in cancer to accelerate metastasis and tumorigenesis. REGγ, a proteasome activator known to promote p53/p21/p16 degradation, is often overexpressed in cancer cells. Here we show that p53/TGF-β signalling inhibits the REGγ-20S proteasome pathway by repressing REGγ expression. Smad3 and p53 interact on the REGγ promoter via the p53RE/SBE region. Converse...
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ژورنال
عنوان ژورنال: Stem Cell Reports
سال: 2019
ISSN: 2213-6711
DOI: 10.1016/j.stemcr.2019.07.010