The RNA Processing Factor Y14 Participates in DNA Damage Response and Repair
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منابع مشابه
Coilin participates in the suppression of RNA polymerase I in response to cisplatin-induced DNA damage
Coilin is a nuclear phosphoprotein that concentrates within Cajal bodies (CBs) and impacts small nuclear ribonucleoprotein (snRNP) biogenesis. Cisplatin and γ-irradiation, which cause distinct types of DNA damage, both trigger the nucleolar accumulation of coilin, and this temporally coincides with the repression of RNA polymerase I (Pol I) activity. Knockdown of endogenous coilin partially ove...
متن کاملDNA Damage Response and Repair Mechanisms
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The number of factors known to participate in the DNA damage response (DDR) has expanded considerably in recent years to include splicing and alternative splicing factors. While the binding of splicing proteins and ribonucleoprotein complexes to nascent transcripts prevents genomic instability by deterring the formation of RNA/DNA duplexes, splicing factors are also recruited to, or removed fro...
متن کاملY14 governs p53 expression and modulates DNA damage sensitivity
Y14 is a core component of the exon junction complex (EJC), while it also exerts cellular functions independent of the EJC. Depletion of Y14 causes G2/M arrest, DNA damage and apoptosis. Here we show that knockdown of Y14 induces the expression of an alternative spliced isoform of p53, namely p53β, in human cells. Y14, in the context of the EJC, inhibited aberrant exon inclusion during the spli...
متن کاملIntegrator3, a partner of single-stranded DNA-binding protein 1, participates in the DNA damage response.
Single-stranded DNA-binding protein 1 (SSB1) plays an important role in the DNA damage response and maintenance of genomic stability. Here, by using protein affinity purification, we have identified Integrator3 (INT3) as a novel partner of SSB1. INT3 forms a complex with SSB1 by constitutively interacting with SSB1 regardless of DNA damage. However, following DNA damage, along with SSB1, INT3 r...
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ژورنال
عنوان ژورنال: iScience
سال: 2019
ISSN: 2589-0042
DOI: 10.1016/j.isci.2019.03.005