The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase
نویسندگان
چکیده
منابع مشابه
Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases
1 Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America, 2 Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America, 3 W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hop...
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ADP-ribosylation is a common posttranslational modification that may have antiviral properties and impact innate immunity. To regulate this activity, macrodomain proteins enzymatically remove covalently attached ADP-ribose from protein targets. All members of the Coronavirinae, a subfamily of positive-sense RNA viruses, contain a highly conserved macrodomain within nonstructural protein 3 (nsp3...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2021
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.01969-20