The Significance of Digital Gene Expression Profiles
نویسندگان
چکیده
منابع مشابه
The significance of digital gene expression profiles.
Genes differentially expressed in different tissues, during development, or during specific pathologies are of foremost interest to both basic and pharmaceutical research. "Transcript profiles" or "digital Northerns" are generated routinely by partially sequencing thousands of randomly selected clones from relevant cDNA libraries. Differentially expressed genes can then be detected from variati...
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This work reports the development of two significance tests for the comparison of digital expression profiles, based on frequentist and Bayesian points of view, respectively. Both tests are exact, and do not use any asymptotic considerations, thus producing more correct results for low frequency tags than the χ test. The frequentist test uses a tag-customized critical level which minimizes a li...
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Nasal polyposis (NP) is a common chronic inflammatory disease of the rhinosinus mucosa and a complex disease with strong genetic and environmental components. During the past 10 to 20 yr, many studies have been performed to determine differential gene expression profiles between NP and normal nasal tissues, in order to identify susceptible genes that are associated with NP-related traits. Despi...
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S.K. Ng , G. J. McLachlan , K. Wang , L. Ben-Tovim Jones , S-W. Ng Department of Mathematics, University of Queensland, Australia e-mail: [email protected] Institute for Molecular Bioscience, University of Queensland, Australia ARC Centre for Complex Systems, University of Queensland, Australia Laboratory of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, ...
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ژورنال
عنوان ژورنال: Genome Research
سال: 1997
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.7.10.986