THE SPLA2 INHIBITION TO DECREASE ENZYME RELEASE AFTER PERCUTANEOUS CORONARY INTERVENTION (SPIDER-PCI) TRIAL.
نویسندگان
چکیده
منابع مشابه
The sPLA2 Inhibition to Decrease Enzyme Release after Percutaneous Coronary Intervention (SPIDER-PCI) trial.
BACKGROUND Secretory phospholipase A(2) (sPLA(2)) may play a role in myonecrosis after elective percutaneous coronary intervention (PCI). Inhibition of this enzyme may have a beneficial effect. The central hypothesis of this study was that treatment with varespladib, a small-molecule inhibitor of sPLA(2) would reduce postprocedural release of cardiac biomarkers after elective percutaneous coron...
متن کاملLetter by Krijnen et al regarding article, "The sPLA2 Inhibition to Decrease Enzyme Release after Percutaneous Coronary Intervention (SPIDER-PCI) trial".
Percutaneous coronary intervention (PCI) may induce a variable amount of myocardial necrosis. It is now well accepted that increased blood levels of the plasma inflammatory marker secretory phospholipase A 2 (sPLA 2) correlate with cardiac injury in patients undergoing PCI, 1 and a role for sPLA 2 in PCI-related cardiac injury has been hypothesized. Using the sPLA 2 inhibitor varespladib, Dzavi...
متن کاملEffect of Melatonin on Cardiac Injury after Primary Percutaneous Coronary Intervention: a Randomized Controlled Trial
Several studies have reported that the antioxidant properties of melatonin can provide cardiac protection through scavenging of free radicals. This study sought to investigate the efficacy of melatonin on cardiac biomarkers, myocardial-specific protein high sensitive troponin-T (hs-TnT) and creatine kinase-MB (CK-MB), in patients with ST-segment elevation myocardial infarction (STEMI) undergoin...
متن کاملEffect of Melatonin on Cardiac Injury after Primary Percutaneous Coronary Intervention: a Randomized Controlled Trial
Several studies have reported that the antioxidant properties of melatonin can provide cardiac protection through scavenging of free radicals. This study sought to investigate the efficacy of melatonin on cardiac biomarkers, myocardial-specific protein high sensitive troponin-T (hs-TnT) and creatine kinase-MB (CK-MB), in patients with ST-segment elevation myocardial infarction (STEMI) undergoin...
متن کاملDecrease of fractional flow reserve shortly after percutaneous coronary intervention.
BACKGROUND The aim of the present study was to quantitatively assess the physiological acute recoil after percutaneous coronary intervention (PCI), and to determine the relation between it and target lesion revascularization (TLR) in the chronic phase. METHODS AND RESULTS This study evaluated 76 patients who underwent elective PCI between May 1997 and December 2001: plain old balloon angiopla...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2010
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(10)61953-5