The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism
نویسندگان
چکیده
منابع مشابه
The structure of Rap1 in complex with RIAM reveals specificity determinants and recruitment mechanism.
The small GTPase Rap1 induces integrin activation via an inside-out signaling pathway mediated by the Rap1-interacting adaptor molecule (RIAM). Blocking this pathway may suppress tumor metastasis and other diseases that are related to hyperactive integrins. However, the molecular basis for the specific recognition of RIAM by Rap1 remains largely unknown. Herein we present the crystal structure ...
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15 صفحه اولRIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.
The small GTPase Rap1 induces integrin-mediated adhesion and changes in the actin cytoskeleton. The mechanisms that mediate these effects of Rap1 are poorly understood. We have identified RIAM as a Rap1-GTP-interacting adaptor molecule. RIAM defines a family of adaptor molecules that contain a RA-like (Ras association) domain, a PH (pleckstrin homology) domain, and various proline-rich motifs. ...
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ژورنال
عنوان ژورنال: Journal of Molecular Cell Biology
سال: 2013
ISSN: 1759-4685,1674-2788
DOI: 10.1093/jmcb/mjt044