Thermosensitivity of the voltage-dependent activation of calcium homeostasis modulator 1 (calhm1) ion channel
نویسندگان
چکیده
منابع مشابه
Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins.
CALHM1 (calcium homeostasis modulator 1) forms a plasma membrane ion channel that mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Six human CALHM homologs exist with no homology to other proteins, although CALHM1 is conserved across >20 species. Here we demonstrate that CALHM1 shares functional and quaternary and secondary structural similarities wit...
متن کاملRare Variants in Calcium Homeostasis Modulator 1 (CALHM1) Found in Early Onset Alzheimer’s Disease Patients Alter Calcium Homeostasis
Calcium signaling in the brain is fundamental to the learning and memory process and there is evidence to suggest that its dysfunction is involved in the pathological pathways underlying Alzheimer's disease (AD). Recently, the calcium hypothesis of AD has received support with the identification of the non-selective Ca(2+)-permeable channel CALHM1. A genetic polymorphism (p. P86L) in CALHM1 red...
متن کاملCalcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability.
Extracellular Ca(2+) (Ca(2+)(o)) plays important roles in physiology. Changes of Ca(2+)(o) concentration ([Ca(2+)](o)) have been observed to modulate neuronal excitability in various physiological and pathophysiological settings, but the mechanisms by which neurons detect [Ca(2+)](o) are not fully understood. Calcium homeostasis modulator 1 (CALHM1) expression was shown to induce cation current...
متن کاملThe effect of stress and glucocorticoids on modulation of pain in mice: Interaction with activation of voltage dependent Ca2+ channel
Previous studies indicated that stress and glucocorticoids have modulatory effects on acute pain. The aim of present study was to determine the interaction between stress and glucocorticoids with activation of voltage dependent Ca2+ channel on modulation of acute pain in mice. Male albino mice (25-30 g) were used for this experiment. Tail flick and hot plate were used for evaluation of analgesi...
متن کاملThe effect of stress and glucocorticoids on modulation of pain in mice: Interaction with activation of voltage dependent Ca2+ channel
Previous studies indicated that stress and glucocorticoids have modulatory effects on acute pain. The aim of present study was to determine the interaction between stress and glucocorticoids with activation of voltage dependent Ca2+ channel on modulation of acute pain in mice. Male albino mice (25-30 g) were used for this experiment. Tail flick and hot plate were used for evaluation of analgesi...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2021
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2020.11.035